![]() With DMSO should not be used in pregnant animals since studies in chick embryosĪnd guinea pigs have indicated it is teratogenic and embryotoxic. With this product without proper supportive antimicrobial therapy. As withĪny corticosteroid, animals with a generalized infection should not be treated Sensitivity testing, and the use of the appropriate antimicrobial agent. Incomplete response or exacerbation of corticosteroid responsive lesions may beĭue to the presence of an infection which requires identification or antibiotic There should be careful initial evaluation and follow-up of infected ears. Avoidįederal law restricts this drug to use by or on the order of Synotic (fluocinolone acetonide and dimethyl sulfoxide) Otic Solution Veterinary is recommended for topical application to the ear canal of the dog only. ![]() Contact of the bare hand with the medication Instillation, gentle external massage of the ear canal may aid in promoting anĮven distribution of the medication. Some appropriate method prior to the instillation of the solution. It is recommended that the affected ear canal be cleansed by Into the ear canal for a maximum period of 14 days. Solution Veterinary is 4 to 6 drops (0.2 mL) per ear administered twice daily Pruritus with its associated scratching and excoriation.ĭosage and Administration: The recommended dose of Synotic Otic Have over 100 times the anti-inflammatory activity of hydrocortisone.įluocinolone acetonide decreases edema, inflammation, erythema, infiltration and Marked anti-inflammatory properties when applied topically. Time to allow distribution and contact with all parts of the ear.įluocinolone acetonide is chemically related to prednisolone and possesses Relatively slow rate of evaporation maintains the solution state for an adequate Spreadability and penetration its drying properties make it valuable in moistĪreas the corticosteroid is highly soluble and stable in this vehicle and a Several useful properties: There is a low surface tension permitting It has been selected for this formulation because of Propylene glycol is well established as being nonsensitizing, nontoxic and hasĪntimicrobial activity. Dimethyl sulfoxide (DMSO) enhances the percutaneous absorption of medications.
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